Aciphex : Drug Information

What is Aciphex?

Aciphex, the generic name is Rabeprazole, is a proton pump inhibitor that treats Helicobacter Pylori symptoms, Gastroesophageal Reflux, and intestinal ulcers. It decreases the amount of acid that is present in the excess in the stomach. It is a short-term medication that solves gastroesophageal reflux disease (GERD) in adults and children at least one-year-old.

In adults, Aciphex treats conditions such as excessive acid in the stomach (Zollinger-Ellison syndrome). Doctors may prescribe you this medication with antibiotics to treat duodenal ulcers caused by the Infection with Helicobacter pylori (H. pylori). Aciphex does not serve you immediate relief in heartburn symptoms.

Important Information

If you are allergic to Rabeprazole or similar medications like esomeprazole (Nexium), lansoprazole (Prevacid), pantoprazole (Protonix), or omeprazole (Prilosec, Zegerid), you should not use Aciphex. This medication is not for instant relief in heartburn situations.

The active ingredient in Aciphex, known as Rabeprazole, may cause kidney problems. Immediately talk to your doctor if your urination is less than usual or having blood in your urine.

Using this medication may cause diarrhea. It is a symptom of some other new infection. Talk to your doctor if you are suffering from watery or bloody diarrhea.

Aciphex may cause worsening symptoms of lupus, sometimes shows new symptoms of lupus also. Immediately contact your doctor and consult with them if this medication is the right fit for you.

If you take this medication improperly, or in excess, or for the long term, it may increase bone fracture risk in the wrist, hip, or spine.

Aciphex comes in the form of a delayed-release sprinkle capsule and delayed-release tablets to take orally. The delayed-release tablets are generally for once a day. Using this medication to treat ulcers, take these tablets once a day after your morning meal. When this medication is combined with other medicines to relieve H. pylori, these tablets are taken twice a day, after your morning meal and evening meal, for one week.

You may take sprinkle capsules once a day, 30 minutes before your meal. Follow all the directions carefully. Misuse of this drug can put you in some life-threatening situation. So do not abuse this medication.

What to know before taking Aciphex?

Talk with your therapist if you are allergic to Rabeprazole, esomeprazole (Nexium), dexlansoprazole (Dexilant), lansoprazole (Prevacid, in Previpac), pantoprazole (Protonix), omeprazole (Prilosec, in Zegerid), or any other ingredients of Rabeprazole. Ask your doctor for the complete list of ingredients in Rabeprazole.

Your doctor should know if you are under the treatment of rilpivirine (Edurant, in Odefsey, Complera). If you are currently taking this medicine, your doctor may suggest you stop taking Aciphex. Rilpivirine may interact with Rabeprazole and harm you physically or mentally.

If you are already taking or plan to take vitamins, herbal products, or nutritional supplements, tell your therapist. It may not be suitable for your health if you take these with Aciphex.

Your doctor should know if you have or ever had a low level of vitamin B-12 in your body, a low level of magnesium in your blood, an autoimmune disease such as systemic lupus erythematosus, or liver disease.

If you are a breastfeeding or pregnant woman, please consult with the doctor before taking this medication. If you become pregnant during Aciphex therapy, call your doctor as soon as you recognize it.

Before taking this medication, you must talk with your doctor about every risk and benefit of Aciphex. Do not take this drug longer than your prescription if you are above 70 years old.

How to take Aciphex?

Generally, you can take this medication once a day, but you must follow all the doctor’s direction, read all the medication guides carefully that comes with the medicine. Use this medicine exactly as your doctor suggests you take it.

It is a medication that you should use for the short-term only, generally four to eight weeks. If your body needs extra healing time, your doctor may start the second course of this medication.

Aciphex is not for children younger than one-year-old.

Take a glass of water and swallow the whole tablet. Do not chew, crush, or break this medication.

If you are using this medicine to treat duodenal ulcers, you can take it after a meal. If you are using it to relieve ulcers due to Helicobacter pylori, you can take this medicine with food. If you are using this medication for other purposes, you can take it with or without food.

You do not need to swallow the delayed-release capsule whole. You can open it and sprinkle the drug into a spoonful of soft food such as yogurt, applesauce, or baby food made from vegetables or fruit. You can mix this medication with apple juice, infant formula, or Pedialyte also. It would be best if you swallowed the whole mixture without chewing. Do not save the drug for later use.

Aciphex dosage

Usual Adult Dosage for the Erosive Esophagitis and ulcerative gastroesophageal reflux disease (GERD);

This medication’s usual dosage is 20mg orally, once a day, for four to eight weeks. If the patient’s symptoms are still not going during this period, the doctors may consider another eight weeks.

Usual Adult Dosage for Duodenal Ulcer;

The usual dosage is 20mg, orally once a day for four weeks. Some patients may need additional time to heal.

Usual Adult Dosage for Gastric Ulcer;

The usual dosage is 20mg orally once a day for the duration of four to eight weeks. Another eight weeks are allowed for those patients who do not heal in a given period.

Usual Dosage for Duodenal Ulcer Prophylaxis;

The usual dosage is 20mg once a day for 12 months. This duration is not extendable for the patients.

Usual Dosage for Gastroesophageal Reflux Disease;

The usual dosage is 20mg orally once a day for four weeks. Another four weeks are allowed for the patient; if symptoms are not gone during this period,

Usual Adult Dosage for Helicobacter pylori Infection;

The usual dosage is 20mg orally, two times a day, with the combination of clarithromycin and amoxicillin for seven days.

Usual Dosage for Zollinger-Ellison Syndrome;

The initial dosage is 60mg once a day; the maintenance dosage is 60mg orally two times a day or 100mg by mouth once a day.

Usual Pediatric Dosage for Gastroesophageal Reflux Disease;

  • For 1 to 11 years:

The recommended dosage for less than 15 kg child is 5mg orally once a day for the duration of upto 12 weeks.

The recommended dosage for 15kg or more is 10mg orally once a day for the duration of upto 12 weeks.

  • For 12 years or older:

The recommended dosage is 20mg orally once a day for the duration of upto eight weeks.


If you take this medication in excess, immediately call the Poison Help line at 1-800-222-1222.

Immediately seek a medical emergency if you do not feel well.

What to avoid while using Aciphex?

This medicine can affect the result of several medical tests. If any doctor suggests you for medical tests, please tell him that you are currently using Aciphex.

Sometimes Aciphex is prescribed with a combination of antibiotics to treat certain medical conditions. Use all the medication according to their doses. Do not take any drug in excess, or do not leave or take only one medicine.

Take Aciphex precisely for the prescribed length, do not take it longer or leave it without completing the full course. Your symptoms may stop to show, but it is not the situation that you are entirely free from your disease.

Talk with your therapist if your symptoms do not improve or getting worse during Aciphex therapy.

Store this medication at 20 degrees centigrade (room temperature) and away from heat and moisture.

Aciphex side effects

An active ingredient in Aciphex can cause side-effects, some of them are common, and some are severe. Consult with your therapist if symptoms that are listed below are not going away;

  • Headache
  • Constipation
  • Diarrhea
  • Gas
  • Nausea
  • Vomiting
  • Sore throat

Take it seriously and immediately call your doctor if you feel;

  • severe diarrhea with watery stools, fever, or stomach pain
  • blistering or peeling skin
  • difficulty breathing or swallowing
  • rash
  • hives
  • swelling of the eyes, face, mouth, lips, tongue, or throat
  • irregular, fast, or pounding heartbeat
  • dizziness
  • excessive tiredness
  • lightheadedness
  • muscle spasms, cramps, or weakness
  • jitteriness
  • uncontrollable shaking of a part of the body
  • seizures
  • new worsening joint pain
  • decreased urination
  • blood in the urine
  • rash on cheeks or arms that is sensitive to sunlight

What drugs can interact with Aciphex?

Before taking this medication, be sure that your doctor knows about the following if you are already taking;

  • certain antibiotics
  • anticoagulants (‘blood thinners’) such as warfarin (Coumadin)
  • atazanavir (Reyataz)
  • cyclosporine (Neoral
  • Sandimmune)
  • dasatinib (Sprycel)
  • digoxin (Lanoxin)
  • diuretics (‘water pills’)
  • erlotinib (Tarceva)
  • itraconazole (Onmel, Sporanox)
  • ketoconazole (Nizoral)
  • iron supplements
  • methotrexate (Trexall, Xatmep)
  • mycophenolate mofetil (Cellcept)
  • nelfinavir (Viracept)
  • nilotinib (Tasigna)
  • saquinavir (Invirase)
  • tacrolimus (Prograf)

The given medication may interact with Aciphex and may become fatal for you.

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