What is Bactrim DS?

Bactrim is a combination of two antibiotics known as sulfamethoxazole and trimethoprim. This medication treats various bacterial infections such as urine, respiratory, middle ear, and intestinal disorders. It can also treat and prevent a specific type of pneumonia (pneumocystis-type). This medication is not for children less than two months of age due to the chance of severe side effects. This medication treats only specific types of infections. It will not act on viral infections such as flu or cold. Unnecessary use or misuse of this medicine may lead to its reduced effectiveness.

Important Information

You should not use this medication if you have severe kidney disease a liver disease not monitored by any doctor or physician. This medication is not for you if you suffer from anemia caused by folic acid deficiency, taking dofetilide, or low platelets caused by a sulfa drug or trimethoprim. You should not use sulfamethoxazole and trimethoprim if you are breastfeeding your baby or you are pregnant.

What to know before taking Bactrim DS?

This drug is not a good option for you if you are allergic to sulfamethoxazole or trimethoprim, or if you are suffering from;

  • kidney disease that is not under any treatment or monitoring
  • severe liver disease
  • anemia or low red blood cells due to folic acid deficiency
  • a history of low blood platelets after taking any sulfa drug or trimethoprim
  • if you take dofetilide (Tikosyn)

Do not use this treatment option if you are pregnant. Use efficient birth control, and inform your doctor if you become pregnant during this therapy. Do not breastfeed your newborn while using this medicine. This medicine is not a treatment for a child younger than two months old. Take help of your health care provider if you have ever had;

  • HIV or AIDS
  • malnourishment
  • a folate (folic acid) deficiency
  • kidney or liver disease
  • asthma or severe allergies
  • a thyroid disorder
  • alcoholism
  • high levels of potassium in your blood
  • porphyria, or glucose-6-phosphate dehydrogenase (G6PD) deficiency
  • if you use a blood thinner (such as warfarin) and you have routine "INR" or prothrombin time tests

How to take Bactrim DS?

You can take Bactrim DS orally. Follow all regulations on your prescription tag and read all remedy guides or instruction sheets. Use the drug exactly as directed. Drink lots of fluids and water to stop kidney stones while you are taking this medicine. Sulfamethoxazole and trimethoprim doses depend on the weight in children. Just use the prescribed dosage when administering this medicine to a child. Use this drug for the full directed length of time, even if your signs quickly improve. Skipping doses can raise your risk of infection that is immune to medication. This medicine will not manage a viral infection such as a common cold or the flu. You may need regular medical tests. This medicine can alter the results of specific medical tests. Report any doctor who treats you that you are under the treatment of sulfamethoxazole and trimethoprim. Store Bactrim DS at room temperature and away from heat, moisture, and light.

Bactrim DS dosage

Adult Dosage: This medication's usual adult dosage is one DS (double strength) tablet or two regular tablets every 12 hours for five days to treat shigellosis and travelers' diarrhea. This medication's recommended dosage is one DS (double strength) tablet or two regular tablets every 12 hours for 10–14 days to treat UTIs. This medication's recommended dosage for bronchitis treatment is one DS (double strength) tablet or two regular tablets every 12 hours for 14 days. For the PJP treatment, this medication's usual adult dosage is 15mg/kg to 20mg/kg every day.

For the treatment of the symptoms of PJP prophylaxis, the recommended dosage is one DS tablet daily. Children Dosage: For less than 2 months: do not use this medication. For the above 2 months: The usual dosage of trimethoprim is 8mg/kg every day and of sulfamethoxazole is 40mg/kg every day in 2 equally divided doses every 12-hour intervals for five days (shigellosis) or ten days to treat otitis media and UTIs. For the PJP treatment in children: The recommended dosage is the same as for an adult.


The overdosing symptoms of Bactrim DS may include loss of appetite, blood in your urine, vomiting, fever, yellowing of your eyes or skin, confusion, or loss of consciousness. Immediately seek emergency medical consideration or call on the Poison Help line number at 1-800-222-1222.

What to avoid while using Bactrim DS?

The antibiotic medicines may cause bloody or watery diarrhea, which may sign a new type of infection. If you suffer from bloody or watery diarrhea, visit your physician before using any anti-diarrhea medicine. Bactrim DS may make you sunburn more quickly, avoid sunlight or tanning beds, wear protective clothing, and use sunscreen (SPF 30 or higher) when you are traveling outdoors.

Bactrim DS side effects

Seek emergency medical attention immediately if you have signs of an allergic reaction such as cough, shortness of breath, hives, or swelling in your throat or face. Immediately take your health care provider's help if you have a severe skin reaction such as sore throat, burning eyes, skin pain, fever, red or purple skin rash with peeling and blistering after using this medication. Visit your physician at once if you have;

  • a skin rash, no matter how mild
  • Watery or bloody diarrhea (even if it occurs in the last months of your dosage), severe stomach pain,
  • yellowing of your skin or eyes
  • a seizure
  • new or unusual joint pain
  • increased or decreased urination
  • increased thirst, dry mouth, fruity breath odor
  • swelling, bruising, or irritation around the IV needle
  • confusion, weakness, slurred speech, tingly feeling, an electrolyte imbalance--headache, chest pain, irregular heartbeats, loss of coordination or movement, feeling unsteady
  • chills, mouth sores, skin sores, easy bruising, skin, cold hands, and feet, low blood cell counts--fever, unusual bleeding, pale feeling light-headed or short of breath

Common side effects of Bactrim DS may include:

  • nausea, loss of appetite, vomiting
  • mild itching or rash

The above list is not a complete list of all the possible side effects of this medication. Other general or severe side effects may occur. Consult your healthcare provider about all the potential side effects of this drug. You may report other side effects to FDA at 1-800-FDA-1088.

What drugs can interact with Bactrim DS?

You may need more medical tests or routine check-ups if you also use medicine to treat diabetes, seizures, depression, or HIV. Many other drugs can interact with Bactrim DS, and you can not use them together. Inform your therapist about all your current medications, especially;

  • amantadine
  • cyclosporine
  • indomethacin
  • leucovorin
  • methotrexate
  • pyrimethamine
  • an "ACE inhibitor" blood pressure or heart medication such as benazepril, enalapril, lisinopril, quinapril, ramipril, and others
  • a diuretic or "water pill" (chlorthalidone, hydrochlorothiazide, and others)

This list does not contain the whole medicines that can interact with Bactrim DS, and many other remedies may affect Bactrim DS's working. Prescription and over-the-counter drugs such as vitamins and herbal products may also affect Bactrim DS's working, so be careful if you are using other medication with it. Not all possible medicine interactions are listed here. Before using other medications with Bactrim DS, please consult your health care provider that they are not harmful to your body if you use them along with this medication.